Description

Nanosized diamond crystals (nanodiamonds, NDs) without any synthetically installed (bio)organic interface enable the specific and efficient targeting of the family of extracellular signaling molecules known as fibroblast growth factors (FGFs). At certain conditions, the ND strongly associate with multiple FGF ligands present at sub-nanomolar concentrations and effectively neutralize the effects of FGF signaling in cells without interfering with other growth factor systems and serum proteins unrelated to FGFs. The interaction of nanodiamonds, as purely inorganic nanoparticles, with proteins, can mitigate pathological FGF signaling and promote the restoration of cartilage growth in a mouse limb explant model.

IP protection status

European patent pending + filled in PCT (technology developed in cooperation with Institute of Organic Chemistry and Biochemistry of the CAS, Prague)